Discover the therapeutic potential of L-Carnosine and its derivatives in treating vascular complications, diabetes, cancer, neurodegenerative diseases, and schizophrenia.
Abstract Summary:
- Vascular complications, including atherosclerosis, diabetic nephropathy, and retinopathy, are severe manifestations of diabetes.
- Advanced Glycation (AGEs) and Lipoxidation (ALEs) end-products contribute to these complications.
- L-Carnosine acts as a quencher of the AGE/ALE precursors Reactive Carbonyl Species (RCS), which are reactive aldehydes derived from oxidative and non-oxidative modifications of sugars and lipids.
- L-Carnosine has shown effectiveness in several disease models where glyco/lipoxidation plays a central pathogenic role.
- L-Carnosine's use as a dietary supplement would require multiple daily doses due to its rapid turnover in the body because of serum and tissue carnosinase enzymes.
- Strategies are being developed based on resistance of L-Carnosine analogs to enzymatic turnover or β-alanine supplementation.
Other Noted Benefits:
- L-Carnosine and its derivatives are potential therapeutic agents in many diseases, including cancer, neurodegenerative diseases, diabetes, and schizophrenia.
- L-Carnosine can prevent long-term glucose toxicity resulting from insufficient glucose-lowering therapy and lipotoxicity.
- It may help reduce the clinical and economic burden of vascular complications of diabetes and related metabolic disorders.