Discover the potential anti-cancer benefits of L-Carnosine in promoting healthy aging and maintaining cellular homeostasis.
Abstract Summary:
- L-Carnosine is a naturally occurring dipeptide found in meat and can also be synthesized from the amino acids, β-alanine and L-histidine.
- It has been advocated for use as an antioxidant and anti-glycating agent to promote healthy aging.
- There have been reports of L-Carnosine having anti-proliferative effects beneficial against the development of various cancers.
- L-Carnosine can undertake multiple molecular processes, but its mechanism of action remains controversial in both healthy tissues and those associated with cancer or metabolic diseases.
- The article reviews the current understanding of its mechanistic role in different physiological contexts related to cancer.
- L-Carnosine turns over rapidly in the body due to the presence of serum and tissue carnosinase enzymes. Therefore, its use as a dietary supplement would require multiple daily doses.
- Strategies are being developed based on resistance of L-Carnosine analogs to enzymatic turnover or β-alanine supplementation.
Other Noted Benefits:
- L-Carnosine has anti-oxidant and anti-glycating properties that facilitate healthy aging.
It has anti-proliferative effects beneficial against various cancers. - L-Carnosine can scavenge reactive species.
Source: https://www.sciencedirect.com/science/article/pii/S0167488921001713?via%3Dihub