Discover the potential anti-cancer effects of L-Carnosine, a dipeptide molecule with various health benefits.
Abstract Summary:
- L-Carnosine is a dipeptide molecule (β-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties.
- It is used in exercise physiology as a food supplement to increase performance; however, in vitro evidence suggests that L-Carnosine may exhibit anti-cancer properties.
- The study investigated the effect of L-Carnosine on breast, ovarian, colon, and leukemic cancer cell proliferation.
- L-Carnosine inhibits breast, ovarian, colon, and leukemic cancer cell proliferation.
- It upregulates the expression of pro-inflammatory molecules, modulates cytokine secretion, and alters U937 differentiation and phenotype.
- The findings suggest potential implications for L-Carnosine in anti-cancer therapy.
Other Noted Benefits:
- L-Carnosine has anti-inflammatory, antioxidant, anti-glycation, and chelating properties.
It can inhibit the proliferation of various cancer cells. - L-Carnosine upregulates the expression of pro-inflammatory molecules in U937 cells.
It modulates cytokine secretion, increasing the secretion of IL-10, GM-CSF, and TNF-α, and decreasing the secretion of IL-8. - L-Carnosine alters U937 differentiation and phenotype, suggesting it promotes differentiation to macrophages rather than monocytes.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002160/