Discover the neuroprotective properties of L-Carnosine and its role in combating oxidative stress, inflammation, and protein aggregation.
Abstract Summary:
- L-Carnosine (Car) is an endogenous dipeptide with antioxidant, metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties.
- The biomolecular mechanisms involved in its neuroprotection are not fully understood.
- This study demonstrates that insulin-degrading enzyme (IDE) plays a crucial role in L-L-Carnosine's neuroprotection.
Other Noted Benefits:
- L-Carnosine has therapeutic potential in diseases characterized by abnormal oxidative stress, inflammation, and abnormal protein aggregation, such as diabetes, Alzheimer's disease (AD), and retinal diseases.
- L-Carnosine can interact with macrophage receptors, stimulating their phagocytic activities.
- It can decrease oxidative stress and inflammation in in vitro models of Aβ-induced stress, making it a promising pharmacological tool in the context of Alzheimer's disease pathology.
- L-Carnosine has shown the ability to revert oxidative stress and microglial activation in a transgenic mouse model of Alzheimer's disease.
- Its supplementation counteracts cognitive decline in Alzheimer's disease subjects.
- The study suggests that L-Carnosine exerts neuroprotective effects against Aβ oligomers through the modulation of IDE activity.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121383/