Discover the therapeutic potential of L-Carnosine, a versatile molecule with multiple benefits.
Abstract Summary:
- Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous dipeptide.
- It has a multimodal mechanism of action that includes:
- Detoxification of reactive oxygen and nitrogen species.
- Down-regulation of the production of pro-inflammatory mediators.
- Inhibition of aberrant protein formation.
- Modulation of cells in the peripheral (macrophages) and brain (microglia) immune systems.
- There's a need for coordinated preclinical studies to lay the foundation for future clinical trials.
Other Noted Benefits:
- Carnosine acts as a neurotransmitter.
- Enhances cell energy metabolism.
- Modulates the immune system.
- Modulates the metabolism of nitric oxide (NO) and related species.
- Acts as an anti-glycation and anti-aging agent.
- Chelates heavy metals.
- Modulates the glutamatergic system by up-regulating glutamate transporter 1 and reducing glutamate levels in the CNS.