Discover the potential benefits of L-Carnosine for bone health, including its ability to promote bone growth, inhibit bone resorption, and protect against specific bone diseases.
Abstract Summary:
- L-Carnosine is an essential endogenous dipeptide with anti-inflammatory, anti-aging, anti-crosslinking, antitumor, and immune regulatory effects.
- Numerous studies have shown that L-Carnosine and its compounds promote the proliferation and differentiation of osteoblasts, inhibit osteoclasts, and protect chondrocytes.
- L-Carnosine regulates the cell cycle of bone progenitor cells, the differentiation of bone marrow mesenchymal stem cells, accelerates fracture healing, delays bone tumor development, & ameliorates osteopenia induced by estrogen deficiency or disuse.
- L-Carnosine and its compounds have potential benefits in preventing and treating specific bone diseases, making them potential agents for treating osteoporosis and bone tumors.
Other Noted Benefits:
- L-Carnosine is a natural bioactive dipeptide abundant in skeletal muscles and the nervous system.
- It has anti-inflammatory, antioxidant, anti-aging, and antitumor functions.
- L-Carnosine promotes the synthesis of new bone proteins by osteoblasts, increases alkaline phosphatase activity, induces differentiation of pluripotent mesenchymal stem cells into osteoblasts and chondrocytes, and inhibits bone resorption activity by osteoclasts.
- L-Carnosine reduces oxidative stress reactions by suppressing the release of inflammatory cytokines and inhibiting the expression of inflammatory mediators.
It can also promote wound healing, chelate heavy metal ions, and reduce lactic acid accumulation in muscles, thus increasing muscle endurance and alleviating fatigue.
Source: https://www.spandidos-publications.com/10.3892/mmr.2022.12899